Quantum mechanical formalism of particle beam optics

A general procedure for construction of the formalism of quantum beam optics for any particle is reviewed. The quantum formalism of spin-1/2 particle beam optics is presented starting {\em ab initio} with the Dirac equation. As an example of application the case of normal magnetic quadrupole lens is discussed. In the classical limit the quantum formalism leads to the well-known Lie algebraic formalism of classical particle beam optics.Comment: ReVTeX 06 pages, in Proc. of the 18th Advanced ICFA Beam Dynamics Workshop on Quantum Aspects of Beam Physics (QABP) (15-20 October 2000, Capri, ITALY) Editor: Pisin Chen (World Scientific, Singapore, 2002) http://www.pd.infn.it/~khan/ and http://www.imsc.ernet.in/~jagan

The pathogenesis of Acanthamoeba infections: current status and future implications

Acanthamoeba are opportunistic protozoan parasites that can cause painful, visionthreatening keratitis. However the pathogenesis and pathophysiology of Acanthamoeba keratitis remain incompletely understood. Most cases of Acanthamoeba keratitis develop as a result of poor hygiene in contact lens care but it is unclear how amoebae transmigrate from the environment into the cornea leading to inflammation, photophobia and blindness. Acanthamoeba keratitis has become increasingly important in the past few decades due to increasing populations of contact lens users. The mechanisms associated with the pathogenesis of Acanthamoeba are highly complex, depending on the virulence properties of the parasite, host susceptibility and the environmental conditions. Complete understanding of Acanthamoeba pathogenesis and its associated risks factors should allow us to design strategies for disease prevention and for the rational development of therapeutic interventions against these devastating infections. Acanthamoeba keratitis has become a significant problem in recent years, especially in contact lens wearers exposed to contaminated water